Beauty connects us viscerally to the material universe. Life forms evolved to experience biological connectedness as an absolute necessity for survival. Starting one century ago, however, dominant culture deliberately reversed the mechanism responsible for visceral connection. The resulting disconnection from the material world will continue to have long-lasting negative consequences for human well-being. Christopher Alexander describes how to revive the visceral connecting process, creating conditions for human-centered design in our times. Biological connectedness arises from an organic projection of the designer’s “self” onto the material reality of the object being designed, and to its physical context. Exploring multiple scenarios using informational feedback avoids letting the designer’s ego or imposed images exert a controlling influence. Implementing Alexander’s connecting method could revolutionize design, with the potential to produce a new, nourishing art and architecture. Recent developments in biophilia and neuro-design help to better understand Alexander’s ideas, using results not available at the time he was developing his theory.